Drug interactions
Desflurane + Oxazepam
Severity: Moderate
Desflurane and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines lower the anesthetic requirement of volatile agents and can increase sedation, hypotension and respiratory depression. Recovery from anesthesia may be prolonged.
What this interaction means in plain words
Desflurane and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A receptor potentiation by both agents.
What to do
The anesthesia team should titrate desflurane to effect and monitor ventilation and hemodynamics. Anticipate delayed emergence in patients taking oxazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Oxazepam?
MediHelp rates the interaction as moderate. Desflurane and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines lower the anesthetic requirement of volatile agents and can increase sedation, hypotension and respiratory depression. Recovery from anesthesia may be prolonged.
How serious is the interaction between Desflurane and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The anesthesia team should titrate desflurane to effect and monitor ventilation and hemodynamics. Anticipate delayed emergence in patients taking oxazepam.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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