Drug interactions
Desflurane + Pasireotide
Severity: Moderate
Desflurane and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and cause bradycardia, and volatile anesthetics can compound QT effects. The combination may increase arrhythmia risk perioperatively.
What this interaction means in plain words
Desflurane and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Pasireotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation, with pasireotide-related bradycardia.
What to do
Check baseline ECG and electrolytes before surgery. Monitor ECG and heart rate during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Desflurane with Pasireotide?
MediHelp rates the interaction as moderate. Desflurane and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide can prolong the QT interval and cause bradycardia, and volatile anesthetics can compound QT effects. The combination may increase arrhythmia risk perioperatively.
How serious is the interaction between Desflurane and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes before surgery. Monitor ECG and heart rate during anesthesia.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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