Drug interactions
Desflurane + Pazopanib
Severity: Moderate
Desflurane and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval. Given together during anesthesia, they may add to the risk of torsades de pointes, especially when electrolyte disturbances or other QT-prolonging drugs are also present.
What this interaction means in plain words
Desflurane and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and consider whether pazopanib needs to be held in patients with a long baseline QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Desflurane with Pazopanib?
MediHelp rates the interaction as moderate. Desflurane and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval. Given together during anesthesia, they may add to the risk of torsades de pointes, especially when electrolyte disturbances or other QT-prolonging drugs are also present.
How serious is the interaction between Desflurane and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively and consider whether pazopanib needs to be held in patients with a long baseline QTc.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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