Drug interactions
Desflurane + Pimavanserin
Severity: Moderate
Desflurane and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin carries a QT-prolongation warning and volatile anesthetics can also lengthen repolarization. Combined use may increase the risk of ventricular arrhythmia, particularly in older patients with cardiac disease.
What this interaction means in plain words
Desflurane and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the baseline QTc and correct electrolytes before the procedure. Monitor the ECG continuously during anesthesia and into recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Desflurane with Pimavanserin?
MediHelp rates the interaction as moderate. Desflurane and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin carries a QT-prolongation warning and volatile anesthetics can also lengthen repolarization. Combined use may increase the risk of ventricular arrhythmia, particularly in older patients with cardiac disease.
How serious is the interaction between Desflurane and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline QTc and correct electrolytes before the procedure. Monitor the ECG continuously during anesthesia and into recovery.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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