Drug interactions
Desflurane + Rasagiline
Severity: Moderate
Desflurane and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can alter hemodynamic responses to general anesthesia. Evidence for rasagiline with desflurane is limited.
What this interaction means in plain words
Desflurane and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction through altered catecholamine handling; mechanism not well established.
What to do
Inform the anesthesia team and monitor blood pressure and heart rate throughout. Avoid indirect sympathomimetics and meperidine perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Rasagiline?
MediHelp rates the interaction as moderate. Desflurane and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can alter hemodynamic responses to general anesthesia. Evidence for rasagiline with desflurane is limited.
How serious is the interaction between Desflurane and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor blood pressure and heart rate throughout. Avoid indirect sympathomimetics and meperidine perioperatively.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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