Drug interactions
Desipramine + Deutetrabenazine
Severity: Moderate
Desipramine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and each is associated with QT prolongation, though deutetrabenazine has little effect at recommended doses. Together they may increase drowsiness and, in at-risk patients, arrhythmia.
What this interaction means in plain words
Desipramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and QTc prolongation.
What to do
Monitor sedation and consider an ECG in patients with QT risk factors. Correct electrolyte abnormalities and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Desipramine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Desipramine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and each is associated with QT prolongation, though deutetrabenazine has little effect at recommended doses. Together they may increase drowsiness and, in at-risk patients, arrhythmia.
How serious is the interaction between Desipramine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and consider an ECG in patients with QT risk factors. Correct electrolyte abnormalities and avoid other QT-prolonging drugs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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