Drug interactions
Desipramine + Dutasteride-tamsulosin
Severity: Moderate
Desipramine and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a CYP2D6 substrate and weak inhibitor and has alpha-1 blocking activity that can add to the hypotensive effect of tamsulosin. A pharmacokinetic increase in tamsulosin is possible but small. Orthostatic hypotension is the main concern.
What this interaction means in plain words
Desipramine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade with weak CYP2D6 competition.
What to do
Monitor for orthostatic hypotension and dizziness, especially in older patients. Lower the dose of either drug if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desipramine and Dutasteride-tamsulosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dutasteride-tamsulosin
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Desipramine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a CYP2D6 substrate and weak inhibitor and has alpha-1 blocking activity that can add to the hypotensive effect of tamsulosin. A pharmacokinetic increase in tamsulosin is possible but small. Orthostatic hypotension is the main concern.
How serious is the interaction between Desipramine and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness, especially in older patients. Lower the dose of either drug if symptomatic.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
