Drug interactions
Desipramine + Flavoxate
Severity: Minor
Desipramine and Flavoxate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine has anticholinergic properties, though less than amitriptyline, and flavoxate adds antimuscarinic effects. The combination may increase dry mouth, constipation and urinary retention.
What this interaction means in plain words
Desipramine and Flavoxate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Flavoxate belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic symptoms, particularly urinary retention and constipation in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Flavoxate?
MediHelp rates the interaction as minor. Desipramine and Flavoxate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desipramine has anticholinergic properties, though less than amitriptyline, and flavoxate adds antimuscarinic effects. The combination may increase dry mouth, constipation and urinary retention.
How serious is the interaction between Desipramine and Flavoxate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, particularly urinary retention and constipation in older patients.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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