Drug interactions
Desipramine + Fluticasone-vilanterol
Severity: Major
Desipramine and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of the long-acting beta-agonist vilanterol, leading to tachycardia, blood pressure changes and arrhythmias. Both drugs can also prolong the QT interval, so the combination adds to arrhythmia risk.
What this interaction means in plain words
Desipramine and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Tricyclics reduce noradrenaline reuptake and have quinidine-like cardiac effects, which augments beta-agonist adrenergic stimulation and additively prolongs QTc.
What to do
If the combination is necessary, monitor heart rate, blood pressure and ECG, particularly at initiation and in patients with cardiac disease. Consider an alternative antidepressant or inhaler regimen in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Desipramine and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of the long-acting beta-agonist vilanterol, leading to tachycardia, blood pressure changes and arrhythmias. Both drugs can also prolong the QT interval, so the combination adds to arrhythmia risk.
How serious is the interaction between Desipramine and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is necessary, monitor heart rate, blood pressure and ECG, particularly at initiation and in patients with cardiac disease. Consider an alternative antidepressant or inhaler regimen in high-risk patients.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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