Drug interactions
Desipramine + Fostemsavir
Severity: Moderate
Desipramine and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QT prolongation at supratherapeutic doses, and desipramine can also prolong the QT interval. Risk of arrhythmia increases with additional risk factors.
What this interaction means in plain words
Desipramine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor the QTc if other risk factors are present. Correct electrolyte abnormalities and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Desipramine with Fostemsavir?
MediHelp rates the interaction as moderate. Desipramine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QT prolongation at supratherapeutic doses, and desipramine can also prolong the QT interval. Risk of arrhythmia increases with additional risk factors.
How serious is the interaction between Desipramine and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc if other risk factors are present. Correct electrolyte abnormalities and avoid further QT-prolonging drugs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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