Drug interactions
Desipramine + Glimepiride
Severity: Minor
Desipramine and Glimepiride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may alter glucose control and occasionally enhance the hypoglycemic effect of sulfonylureas. Clinical impact is usually small.
What this interaction means in plain words
Desipramine and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Glimepiride belongs to Endocrine.
Why it happens
Possible pharmacodynamic enhancement of hypoglycemia; the mechanism is not clearly established.
What to do
Monitor blood glucose when desipramine is started or stopped, and adjust the glimepiride dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Glimepiride
Frequently asked questions
Can I take Desipramine with Glimepiride?
MediHelp rates the interaction as minor. Desipramine and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may alter glucose control and occasionally enhance the hypoglycemic effect of sulfonylureas. Clinical impact is usually small.
How serious is the interaction between Desipramine and Glimepiride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when desipramine is started or stopped, and adjust the glimepiride dose if control changes.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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