Drug interactions
Desipramine + Glycopyrronium
Severity: Moderate
Desipramine and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine has anticholinergic activity, although less than some other tricyclics. With glycopyrronium it can contribute to additive dry mouth, constipation, urinary hesitancy and tachycardia.
What this interaction means in plain words
Desipramine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
Why it happens
Additive pharmacodynamic antimuscarinic effects.
What to do
Monitor for anticholinergic symptoms and heart rate, and reduce the glycopyrronium dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Glycopyrronium?
MediHelp rates the interaction as moderate. Desipramine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine has anticholinergic activity, although less than some other tricyclics. With glycopyrronium it can contribute to additive dry mouth, constipation, urinary hesitancy and tachycardia.
How serious is the interaction between Desipramine and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and heart rate, and reduce the glycopyrronium dose if adverse effects appear.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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