Drug interactions
Desipramine + Isoproterenol
Severity: Moderate
Desipramine and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics may potentiate the cardiovascular effects of direct beta-agonist sympathomimetics, increasing the risk of tachycardia and arrhythmias. The effect is less pronounced than with norepinephrine or epinephrine because isoproterenol is not taken up by neuronal reuptake.
What this interaction means in plain words
Desipramine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Altered adrenergic sensitivity and tricyclic effects on catecholamine disposition; the mechanism is incompletely established.
What to do
Monitor heart rate, blood pressure and ECG during isoproterenol use, and titrate to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Desipramine with Isoproterenol?
MediHelp rates the interaction as moderate. Desipramine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics may potentiate the cardiovascular effects of direct beta-agonist sympathomimetics, increasing the risk of tachycardia and arrhythmias. The effect is less pronounced than with norepinephrine or epinephrine because isoproterenol is not taken up by neuronal reuptake.
How serious is the interaction between Desipramine and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during isoproterenol use, and titrate to the lowest effective dose.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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