Drug interactions
Desipramine + Lemborexant
Severity: Moderate
Desipramine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have CNS depressant effects, so together they may increase somnolence and next-day impairment. Psychomotor performance and driving ability may be affected.
What this interaction means in plain words
Desipramine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and tricyclic sedative effects.
What to do
Use the lowest effective lemborexant dose and counsel patients about next-day impairment. Reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Desipramine with Lemborexant?
MediHelp rates the interaction as moderate. Desipramine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have CNS depressant effects, so together they may increase somnolence and next-day impairment. Psychomotor performance and driving ability may be affected.
How serious is the interaction between Desipramine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and counsel patients about next-day impairment. Reduce the dose if excessive sedation occurs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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