Drug interactions
Desipramine + Levetiracetam
Severity: Minor
Desipramine and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, so combined use may amplify sedation and impair alertness. Tricyclics may also lower the seizure threshold, which can work against the purpose of levetiracetam in epilepsy.
What this interaction means in plain words
Desipramine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depression; no significant pharmacokinetic interaction is expected.
What to do
Counsel the patient about sedation and driving. Watch seizure control if desipramine is started in a patient with epilepsy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Desipramine with Levetiracetam?
MediHelp rates the interaction as minor. Desipramine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness and dizziness, so combined use may amplify sedation and impair alertness. Tricyclics may also lower the seizure threshold, which can work against the purpose of levetiracetam in epilepsy.
How serious is the interaction between Desipramine and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about sedation and driving. Watch seizure control if desipramine is started in a patient with epilepsy.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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