Drug interactions
Desipramine + Linagliptin-metformin
Severity: Minor
Desipramine and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may alter glucose regulation and have occasionally been associated with enhanced hypoglycemia. The effect with metformin is small and inconsistent.
What this interaction means in plain words
Desipramine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
Possible pharmacodynamic effects on glucose and insulin regulation; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping desipramine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Linagliptin-metformin?
MediHelp rates the interaction as minor. Desipramine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may alter glucose regulation and have occasionally been associated with enhanced hypoglycemia. The effect with metformin is small and inconsistent.
How serious is the interaction between Desipramine and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping desipramine.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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