Drug interactions
Desipramine + Methocarbamol
Severity: Moderate
Desipramine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a tricyclic antidepressant that is less sedating than some others but can still cause drowsiness and dizziness. With methocarbamol, additive sedation and impaired psychomotor performance are possible.
What this interaction means in plain words
Desipramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of a tricyclic antidepressant and a centrally acting muscle relaxant.
What to do
Monitor for drowsiness, confusion and falls, especially in older patients. Adjust the dose of either drug if sedation interferes with daily function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Methocarbamol?
MediHelp rates the interaction as moderate. Desipramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a tricyclic antidepressant that is less sedating than some others but can still cause drowsiness and dizziness. With methocarbamol, additive sedation and impaired psychomotor performance are possible.
How serious is the interaction between Desipramine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, confusion and falls, especially in older patients. Adjust the dose of either drug if sedation interferes with daily function.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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