Drug interactions
Desipramine + Methohexital
Severity: Moderate
Desipramine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, so the combination may cause deeper sedation, hypotension and respiratory depression during anesthesia. Tricyclics may also lower seizure threshold.
What this interaction means in plain words
Desipramine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Titrate methohexital carefully with continuous monitoring of respiration, oxygenation and blood pressure, and inform the anesthesia team of tricyclic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Desipramine with Methohexital?
MediHelp rates the interaction as moderate. Desipramine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, so the combination may cause deeper sedation, hypotension and respiratory depression during anesthesia. Tricyclics may also lower seizure threshold.
How serious is the interaction between Desipramine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully with continuous monitoring of respiration, oxygenation and blood pressure, and inform the anesthesia team of tricyclic use.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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