Drug interactions
Desipramine + Mifepristone
Severity: Major
Desipramine and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can prolong the QT interval, and desipramine also has QT-prolonging and proarrhythmic potential. In addition, mifepristone inhibits CYP2D6 and may raise desipramine concentrations, increasing the risk of toxicity and arrhythmia.
What this interaction means in plain words
Desipramine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Additive QT prolongation plus CYP2D6 inhibition by mifepristone reducing desipramine clearance.
What to do
Avoid the combination if possible. If needed, use the lowest desipramine dose, monitor ECG and desipramine levels, and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Desipramine with Mifepristone?
MediHelp rates the interaction as major. Desipramine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone can prolong the QT interval, and desipramine also has QT-prolonging and proarrhythmic potential. In addition, mifepristone inhibits CYP2D6 and may raise desipramine concentrations, increasing the risk of toxicity and arrhythmia.
How serious is the interaction between Desipramine and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If needed, use the lowest desipramine dose, monitor ECG and desipramine levels, and correct electrolyte abnormalities.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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