Drug interactions
Desipramine + Naldemedine
Severity: Minor
Desipramine and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a CYP3A4 substrate, but desipramine is not a significant CYP3A4 inhibitor. A clinically relevant increase in naldemedine exposure is therefore not expected.
What this interaction means in plain words
Desipramine and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
No meaningful CYP3A4 inhibition by desipramine, so the interaction is largely theoretical.
What to do
No dose adjustment is needed. Monitor for gastrointestinal adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Desipramine with Naldemedine?
MediHelp rates the interaction as minor. Desipramine and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a CYP3A4 substrate, but desipramine is not a significant CYP3A4 inhibitor. A clinically relevant increase in naldemedine exposure is therefore not expected.
How serious is the interaction between Desipramine and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for gastrointestinal adverse effects as usual.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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