Drug interactions
Desipramine + Naratriptan
Severity: Moderate
Desipramine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with a tricyclic antidepressant has been linked to serotonin syndrome in rare reports. The absolute risk appears low, but it matters because symptoms can escalate quickly.
What this interaction means in plain words
Desipramine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects (5-HT1B/1D agonism plus inhibition of serotonin reuptake).
What to do
Counsel patients to report agitation, tremor, sweating, fever or diarrhea, and stop both drugs if serotonin syndrome is suspected. Monitor especially when doses are increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Desipramine with Naratriptan?
MediHelp rates the interaction as moderate. Desipramine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with a tricyclic antidepressant has been linked to serotonin syndrome in rare reports. The absolute risk appears low, but it matters because symptoms can escalate quickly.
How serious is the interaction between Desipramine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, sweating, fever or diarrhea, and stop both drugs if serotonin syndrome is suspected. Monitor especially when doses are increased.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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