Drug interactions
Desipramine + Oliceridine
Severity: Major
Desipramine and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause CNS depression, and opioids with tricyclic antidepressants carry a risk of serotonergic effects. Desipramine's anticholinergic activity may add to opioid-related constipation and urinary retention. Respiratory depression and sedation may be enhanced.
What this interaction means in plain words
Desipramine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, plus additive anticholinergic effects on gut and bladder and a possible serotonergic contribution.
What to do
Start oliceridine at the lowest dose and titrate carefully while monitoring sedation and respiratory rate. Monitor for urinary retention, constipation and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Desipramine with Oliceridine?
MediHelp rates the interaction as major. Desipramine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can cause CNS depression, and opioids with tricyclic antidepressants carry a risk of serotonergic effects. Desipramine's anticholinergic activity may add to opioid-related constipation and urinary retention. Respiratory depression and sedation may be enhanced.
How serious is the interaction between Desipramine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start oliceridine at the lowest dose and titrate carefully while monitoring sedation and respiratory rate. Monitor for urinary retention, constipation and signs of serotonin toxicity.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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