Drug interactions
Desipramine + Orphenadrin
Severity: Moderate
Desipramine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a tricyclic antidepressant with anticholinergic and sedative effects, though less than some others in its class. With orphenadrine the combination can increase anticholinergic burden, sedation and confusion.
What this interaction means in plain words
Desipramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive muscarinic blockade and central sedative effects.
What to do
Monitor for anticholinergic toxicity and sedation, and lower doses if needed. Avoid in older patients and those with glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Orphenadrin?
MediHelp rates the interaction as moderate. Desipramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a tricyclic antidepressant with anticholinergic and sedative effects, though less than some others in its class. With orphenadrine the combination can increase anticholinergic burden, sedation and confusion.
How serious is the interaction between Desipramine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and lower doses if needed. Avoid in older patients and those with glaucoma or urinary retention.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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