Drug interactions
Desipramine + Pilocarpine
Severity: Minor
Desipramine and Pilocarpine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine's anticholinergic activity may counteract the muscarinic agonist effect of pilocarpine. This can lessen relief of dry mouth or reduce miotic effect.
What this interaction means in plain words
Desipramine and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for diminished pilocarpine efficacy and adjust the dose according to response. Consider a less anticholinergic antidepressant if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Desipramine with Pilocarpine?
MediHelp rates the interaction as minor. Desipramine and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desipramine's anticholinergic activity may counteract the muscarinic agonist effect of pilocarpine. This can lessen relief of dry mouth or reduce miotic effect.
How serious is the interaction between Desipramine and Pilocarpine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished pilocarpine efficacy and adjust the dose according to response. Consider a less anticholinergic antidepressant if needed.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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