Drug interactions
Desipramine + Quizartinib
Severity: Major
Desipramine and Quizartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval and its labeling warns against combining it with other QT-prolonging drugs. Desipramine adds to this risk and could contribute to torsades de pointes or sudden cardiac death.
What this interaction means in plain words
Desipramine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Additive inhibition of cardiac repolarisation, prolonging the QT interval.
What to do
Prefer a non-QT-prolonging antidepressant where possible. If both are necessary, monitor ECG frequently, correct electrolytes and reduce quizartinib dose or interrupt if QTc rises substantially.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Desipramine with Quizartinib?
MediHelp rates the interaction as major. Desipramine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval and its labeling warns against combining it with other QT-prolonging drugs. Desipramine adds to this risk and could contribute to torsades de pointes or sudden cardiac death.
How serious is the interaction between Desipramine and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antidepressant where possible. If both are necessary, monitor ECG frequently, correct electrolytes and reduce quizartinib dose or interrupt if QTc rises substantially.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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