Drug interactions
Desipramine + Tamsulosin
Severity: Moderate
Desipramine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a CYP2D6 substrate with weak inhibitory effect, and tricyclics have alpha-blocking activity. The combination may cause additive orthostatic hypotension and slightly higher tamsulosin exposure.
What this interaction means in plain words
Desipramine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Additive alpha-1 blockade with possible weak CYP2D6 competition.
What to do
Monitor orthostatic blood pressure and advise slow position changes. Lower the tamsulosin dose if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Tamsulosin?
MediHelp rates the interaction as moderate. Desipramine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a CYP2D6 substrate with weak inhibitory effect, and tricyclics have alpha-blocking activity. The combination may cause additive orthostatic hypotension and slightly higher tamsulosin exposure.
How serious is the interaction between Desipramine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and advise slow position changes. Lower the tamsulosin dose if symptomatic.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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