Drug interactions
Desirudin + Melatonin
Severity: Minor
Desirudin and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin may theoretically add to the bleeding risk of a direct thrombin inhibitor through minor effects on coagulation. Clinical evidence is lacking.
What this interaction means in plain words
Desirudin and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak effect on hemostasis; the mechanism is not established.
What to do
Continue routine aPTT and bleeding monitoring during desirudin therapy; no adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Desirudin with Melatonin?
MediHelp rates the interaction as minor. Desirudin and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin may theoretically add to the bleeding risk of a direct thrombin inhibitor through minor effects on coagulation. Clinical evidence is lacking.
How serious is the interaction between Desirudin and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue routine aPTT and bleeding monitoring during desirudin therapy; no adjustment is needed.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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