Drug interactions
Desloratadine + Erythromycin
Severity: Minor
Desloratadine and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin modestly raises desloratadine concentrations in pharmacokinetic studies, but without meaningful changes in QT interval or in clinical safety. The effect is generally not clinically important.
What this interaction means in plain words
Desloratadine and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Erythromycin belongs to Anti Bacterial.
Why it happens
Possible inhibition of desloratadine metabolism and transport by erythromycin.
What to do
No dose adjustment is required; counsel the patient to report palpitations or excessive sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Frequently asked questions
Can I take Desloratadine with Erythromycin?
MediHelp rates the interaction as minor. Desloratadine and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin modestly raises desloratadine concentrations in pharmacokinetic studies, but without meaningful changes in QT interval or in clinical safety. The effect is generally not clinically important.
How serious is the interaction between Desloratadine and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; counsel the patient to report palpitations or excessive sedation.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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