Drug interactions
Desloratadine + Ketoconazole
Severity: Minor
Desloratadine and Ketoconazole: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole modestly raised desloratadine exposure in pharmacokinetic studies, but this was not accompanied by clinically meaningful changes in safety or QT interval.
What this interaction means in plain words
Desloratadine and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Ketoconazole belongs to Anti Fungals.
Why it happens
Possible inhibition of desloratadine metabolism and transport by ketoconazole.
What to do
No dose adjustment is required. Be aware of the interaction if adverse effects such as excessive drowsiness appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Desloratadine - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Desloratadine with Ketoconazole?
MediHelp rates the interaction as minor. Desloratadine and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole modestly raised desloratadine exposure in pharmacokinetic studies, but this was not accompanied by clinically meaningful changes in safety or QT interval.
How serious is the interaction between Desloratadine and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Be aware of the interaction if adverse effects such as excessive drowsiness appear.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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