Drug interactions
Desloratadine + Phenelzine
Severity: Minor
Desloratadine and Phenelzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as phenelzine may prolong and intensify the sedative and anticholinergic effects of antihistamines. Desloratadine is minimally sedating, so a clinically important effect is not well documented.
What this interaction means in plain words
Desloratadine and Phenelzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Phenelzine belongs to Central Nervous System.
Why it happens
Possible additive CNS depression and potentiation of anticholinergic effects through MAO inhibition.
What to do
Monitor for drowsiness, dry mouth and urinary retention. Reduce the antihistamine dose or stop it if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Desloratadine with Phenelzine?
MediHelp rates the interaction as minor. Desloratadine and Phenelzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors such as phenelzine may prolong and intensify the sedative and anticholinergic effects of antihistamines. Desloratadine is minimally sedating, so a clinically important effect is not well documented.
How serious is the interaction between Desloratadine and Phenelzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness, dry mouth and urinary retention. Reduce the antihistamine dose or stop it if symptoms occur.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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