Drug interactions
Desloratadine + Sotorasib
Severity: Minor
Desloratadine and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak inducer of P-glycoprotein and may modestly lower exposure to P-gp substrates such as desloratadine. This could slightly reduce antihistamine effectiveness.
What this interaction means in plain words
Desloratadine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Sotorasib belongs to Oncology.
Why it happens
Induction of P-glycoprotein by sotorasib increases desloratadine efflux and lowers its absorption.
What to do
No empirical dose change is needed. Monitor for reduced allergy control and adjust therapy if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Desloratadine with Sotorasib?
MediHelp rates the interaction as minor. Desloratadine and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib is a weak inducer of P-glycoprotein and may modestly lower exposure to P-gp substrates such as desloratadine. This could slightly reduce antihistamine effectiveness.
How serious is the interaction between Desloratadine and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for reduced allergy control and adjust therapy if symptoms worsen.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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