Drug interactions
Desogestrel + Glipizide-metformin
Severity: Minor
Desogestrel and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptives containing progestins can modestly impair glucose tolerance and may reduce the glucose-lowering effect of antidiabetics. The effect is usually small with modern low-dose products.
What this interaction means in plain words
Desogestrel and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel belongs to Endocrine; Glipizide-metformin belongs to Endocrine.
Why it happens
Progestins can mildly increase insulin resistance, opposing antidiabetic drugs.
What to do
Monitor glucose when starting or stopping the contraceptive and adjust therapy only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desogestrel and Glipizide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Berotralstat + Desogestrel Moderate
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Mifepristone Moderate
- Desogestrel + Warfarin Moderate
- Alogliptin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Desogestrel with Glipizide-metformin?
MediHelp rates the interaction as minor. Desogestrel and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hormonal contraceptives containing progestins can modestly impair glucose tolerance and may reduce the glucose-lowering effect of antidiabetics. The effect is usually small with modern low-dose products.
How serious is the interaction between Desogestrel and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping the contraceptive and adjust therapy only if control changes.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
