Drug interactions
Desogestrel + Glyburide-metformin
Severity: Minor
Desogestrel and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptives containing desogestrel may slightly impair glucose tolerance in some women. The effect is usually small and is seldom clinically meaningful at current doses.
What this interaction means in plain words
Desogestrel and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel belongs to Endocrine; Glyburide-metformin belongs to Endocrine.
Why it happens
Progestins can cause mild insulin resistance, opposing antidiabetic drug effects.
What to do
Monitor blood glucose when starting or stopping the contraceptive and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Berotralstat + Desogestrel Moderate
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Mifepristone Moderate
- Desogestrel + Warfarin Moderate
- Alogliptin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Desogestrel with Glyburide-metformin?
MediHelp rates the interaction as minor. Desogestrel and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hormonal contraceptives containing desogestrel may slightly impair glucose tolerance in some women. The effect is usually small and is seldom clinically meaningful at current doses.
How serious is the interaction between Desogestrel and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the contraceptive and adjust antidiabetic doses if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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