Drug interactions
Desogestrel + Metformin-repaglinide
Severity: Minor
Desogestrel and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins and combined hormonal contraceptives may reduce glucose tolerance and insulin sensitivity. This can slightly weaken the effect of metformin and repaglinide, although modern low-dose products have only a small effect.
What this interaction means in plain words
Desogestrel and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through hormonal effects on insulin sensitivity.
What to do
Monitor glucose control after starting or stopping the contraceptive and adjust antidiabetic therapy if necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Berotralstat + Desogestrel Moderate
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Mifepristone Moderate
- Desogestrel + Warfarin Moderate
- Alogliptin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Desogestrel with Metformin-repaglinide?
MediHelp rates the interaction as minor. Desogestrel and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins and combined hormonal contraceptives may reduce glucose tolerance and insulin sensitivity. This can slightly weaken the effect of metformin and repaglinide, although modern low-dose products have only a small effect.
How serious is the interaction between Desogestrel and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control after starting or stopping the contraceptive and adjust antidiabetic therapy if necessary.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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