Drug interactions
Desogestrel-ethinyl estradiol + Etravirine
Severity: Moderate
Desogestrel-ethinyl estradiol and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower hormonal contraceptive concentrations. It may also modestly alter ethinyl estradiol exposure, so contraceptive reliability is uncertain.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 by etravirine increases metabolism of contraceptive steroids.
What to do
Use an additional or alternative non-hormonal contraceptive method during etravirine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Etravirine?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower hormonal contraceptive concentrations. It may also modestly alter ethinyl estradiol exposure, so contraceptive reliability is uncertain.
How serious is the interaction between Desogestrel-ethinyl estradiol and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional or alternative non-hormonal contraceptive method during etravirine therapy.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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