Drug interactions
Desogestrel-ethinyl estradiol + Flibanserin
Severity: Moderate
Desogestrel-ethinyl estradiol and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin exposure rises with CYP3A4 inhibitors, and oral contraceptives are weak inhibitors. Labeling notes that multiple weak inhibitors together may increase risks of hypotension, syncope, and CNS depression, though contraceptive use alone has shown modest effect.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Flibanserin belongs to Genitourinary.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol may increase flibanserin exposure.
What to do
Counsel patients on dizziness and sedation, and avoid alcohol; check for other CYP3A4 inhibitors and avoid combining several.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Flibanserin?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin exposure rises with CYP3A4 inhibitors, and oral contraceptives are weak inhibitors. Labeling notes that multiple weak inhibitors together may increase risks of hypotension, syncope, and CNS depression, though contraceptive use alone has shown modest effect.
How serious is the interaction between Desogestrel-ethinyl estradiol and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on dizziness and sedation, and avoid alcohol; check for other CYP3A4 inhibitors and avoid combining several.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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