Drug interactions
Desogestrel-ethinyl estradiol + Iloperidone
Severity: Minor
Desogestrel-ethinyl estradiol and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone may modestly raise ethinyl estradiol exposure through CYP3A4 inhibition. The clinical significance is likely small, but estrogen-related adverse effects could increase.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Iloperidone weakly inhibits CYP3A4, reducing the metabolism of ethinyl estradiol.
What to do
No routine change is needed. Monitor for estrogenic adverse effects such as nausea, breast tenderness or breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Iloperidone?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone may modestly raise ethinyl estradiol exposure through CYP3A4 inhibition. The clinical significance is likely small, but estrogen-related adverse effects could increase.
How serious is the interaction between Desogestrel-ethinyl estradiol and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for estrogenic adverse effects such as nausea, breast tenderness or breakthrough bleeding.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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