Drug interactions
Desogestrel-ethinyl estradiol + Lomitapide
Severity: Major
Desogestrel-ethinyl estradiol and Lomitapide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling advises limiting the dose with weak CYP3A4 inhibitors.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desogestrel-ethinyl estradiol belongs to Endocrine; Lomitapide belongs to Cardiovascular.
Why it happens
Ethinyl estradiol inhibits CYP3A4, decreasing the metabolism of lomitapide.
What to do
Limit lomitapide to the labeled maximum dose with weak CYP3A4 inhibitors and monitor liver enzymes closely. Titrate lomitapide carefully when starting or stopping the contraceptive.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Lomitapide?
MediHelp rates the interaction as major. Desogestrel-ethinyl estradiol and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethinyl estradiol is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling advises limiting the dose with weak CYP3A4 inhibitors.
How serious is the interaction between Desogestrel-ethinyl estradiol and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lomitapide to the labeled maximum dose with weak CYP3A4 inhibitors and monitor liver enzymes closely. Titrate lomitapide carefully when starting or stopping the contraceptive.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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