Drug interactions
Desogestrel-ethinyl estradiol + Lonafarnib
Severity: Moderate
Desogestrel-ethinyl estradiol and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and a CYP3A inhibitor, and its exposure may increase with weak CYP3A inhibitors such as ethinyl estradiol. Its effect on the contraceptive steroids is also possible, and the QT effect of lonafarnib is not well characterized.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Why it happens
Competition for CYP3A metabolism, with lonafarnib also inhibiting CYP3A and CYP2C19 pathways involved in hormone clearance.
What to do
Monitor for lonafarnib adverse effects including gastrointestinal toxicity and arrhythmia symptoms, and adjust the lonafarnib dose per labeling. Consider the need for contraceptive review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Lonafarnib?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate and a CYP3A inhibitor, and its exposure may increase with weak CYP3A inhibitors such as ethinyl estradiol. Its effect on the contraceptive steroids is also possible, and the QT effect of lonafarnib is not well characterized.
How serious is the interaction between Desogestrel-ethinyl estradiol and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects including gastrointestinal toxicity and arrhythmia symptoms, and adjust the lonafarnib dose per labeling. Consider the need for contraceptive review.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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