Drug interactions
Desogestrel-ethinyl estradiol + Ribociclib
Severity: Major
Desogestrel-ethinyl estradiol and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and could raise ethinyl estradiol exposure. In addition, combined hormonal contraceptives are inappropriate in hormone receptor-positive breast cancer, for which ribociclib is used.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desogestrel-ethinyl estradiol belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib reduces ethinyl estradiol metabolism.
What to do
Avoid estrogen-containing contraceptives in patients on ribociclib and use a non-hormonal method such as a copper IUD or barrier method.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Ribociclib?
MediHelp rates the interaction as major. Desogestrel-ethinyl estradiol and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib is a CYP3A4 inhibitor and could raise ethinyl estradiol exposure. In addition, combined hormonal contraceptives are inappropriate in hormone receptor-positive breast cancer, for which ribociclib is used.
How serious is the interaction between Desogestrel-ethinyl estradiol and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing contraceptives in patients on ribociclib and use a non-hormonal method such as a copper IUD or barrier method.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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