Drug interactions
Desogestrel-ethinyl estradiol + Tazemetostat
Severity: Moderate
Desogestrel-ethinyl estradiol and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A inducer and may lower exposure to CYP3A-metabolised hormones, potentially reducing contraceptive efficacy. Tazemetostat is also embryotoxic, so contraceptive failure carries significant consequences.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat weakly induces CYP3A4, increasing the metabolism of ethinyl estradiol and etonogestrel (the active metabolite of desogestrel).
What to do
Advise an additional non-hormonal contraceptive method during tazemetostat treatment and for a period after the last dose as per labeling. Monitor for breakthrough bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Tazemetostat?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak CYP3A inducer and may lower exposure to CYP3A-metabolised hormones, potentially reducing contraceptive efficacy. Tazemetostat is also embryotoxic, so contraceptive failure carries significant consequences.
How serious is the interaction between Desogestrel-ethinyl estradiol and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during tazemetostat treatment and for a period after the last dose as per labeling. Monitor for breakthrough bleeding.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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