Drug interactions
Desogestrel-ethinyl estradiol + Tizanidine
Severity: Moderate
Desogestrel-ethinyl estradiol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is cleared mainly by CYP1A2, and oral contraceptives reduce its clearance. Exposure rises, increasing the risk of hypotension, bradycardia and sedation.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Tizanidine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP1A2-mediated tizanidine metabolism by ethinyl estradiol.
What to do
Start tizanidine at a low dose and titrate cautiously, monitoring blood pressure, heart rate and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Tizanidine?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is cleared mainly by CYP1A2, and oral contraceptives reduce its clearance. Exposure rises, increasing the risk of hypotension, bradycardia and sedation.
How serious is the interaction between Desogestrel-ethinyl estradiol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tizanidine at a low dose and titrate cautiously, monitoring blood pressure, heart rate and sedation.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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