Drug interactions
Desogestrel-ethinyl estradiol + Voriconazole
Severity: Moderate
Desogestrel-ethinyl estradiol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases ethinyl estradiol exposure, and the contraceptive modestly raises voriconazole levels. This may increase estrogenic adverse effects and voriconazole-related effects.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 and CYP2C19 inhibition by voriconazole reduces ethinyl estradiol and progestin metabolism.
What to do
Monitor for estrogen-related adverse effects such as nausea, headache and breast tenderness, and for voriconazole toxicity during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Voriconazole?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole increases ethinyl estradiol exposure, and the contraceptive modestly raises voriconazole levels. This may increase estrogenic adverse effects and voriconazole-related effects.
How serious is the interaction between Desogestrel-ethinyl estradiol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects such as nausea, headache and breast tenderness, and for voriconazole toxicity during co-therapy.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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