Drug interactions
Desvenlafaxine + Difelikefalin
Severity: Minor
Desvenlafaxine and Difelikefalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, which may be additive with the CNS effects of desvenlafaxine. The combination is generally manageable.
What this interaction means in plain words
Desvenlafaxine and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS effects; no pharmacokinetic interaction is expected.
What to do
Monitor for drowsiness and dizziness and counsel patients about driving and fall risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Desvenlafaxine with Difelikefalin?
MediHelp rates the interaction as minor. Desvenlafaxine and Difelikefalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin can cause somnolence and dizziness, which may be additive with the CNS effects of desvenlafaxine. The combination is generally manageable.
How serious is the interaction between Desvenlafaxine and Difelikefalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness and counsel patients about driving and fall risk.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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