Drug interactions
Desvenlafaxine + Flibanserin
Severity: Moderate
Desvenlafaxine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP3A4 inhibitor at most, so a rise in flibanserin exposure is small. Both drugs act on serotonergic systems and can cause sedation, dizziness and hypotension, and flibanserin labeling cautions about combined use with SSRIs and SNRIs.
What this interaction means in plain words
Desvenlafaxine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive serotonergic and CNS effects; possible weak CYP3A4 inhibition.
What to do
Monitor for dizziness, syncope, sedation and serotonergic symptoms. Counsel about bedtime dosing and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Flibanserin?
MediHelp rates the interaction as moderate. Desvenlafaxine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desvenlafaxine is a weak CYP3A4 inhibitor at most, so a rise in flibanserin exposure is small. Both drugs act on serotonergic systems and can cause sedation, dizziness and hypotension, and flibanserin labeling cautions about combined use with SSRIs and SNRIs.
How serious is the interaction between Desvenlafaxine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, syncope, sedation and serotonergic symptoms. Counsel about bedtime dosing and alcohol avoidance.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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