Drug interactions
Desvenlafaxine + Fluphenazine
Severity: Moderate
Desvenlafaxine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine can modestly increase fluphenazine exposure by inhibiting CYP2D6, which may increase extrapyramidal symptoms and sedation. The effect is usually small but can matter in patients who are poor CYP2D6 metabolizers.
What this interaction means in plain words
Desvenlafaxine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition reduces fluphenazine metabolism.
What to do
Monitor for parkinsonism, akathisia and sedation, and lower the fluphenazine dose if these develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Desvenlafaxine with Fluphenazine?
MediHelp rates the interaction as moderate. Desvenlafaxine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desvenlafaxine can modestly increase fluphenazine exposure by inhibiting CYP2D6, which may increase extrapyramidal symptoms and sedation. The effect is usually small but can matter in patients who are poor CYP2D6 metabolizers.
How serious is the interaction between Desvenlafaxine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for parkinsonism, akathisia and sedation, and lower the fluphenazine dose if these develop.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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