Drug interactions
Desvenlafaxine + Granisetron
Severity: Moderate
Desvenlafaxine and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported when 5-HT3 antagonists are given with serotonergic antidepressants. The absolute risk is low, but the reaction can be severe. Features include agitation, tremor, hyperreflexia, sweating and fever.
What this interaction means in plain words
Desvenlafaxine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Possible additive serotonergic effect from serotonin reuptake inhibition combined with 5-HT3 antagonism; the mechanism is not firmly established.
What to do
Counsel the patient and monitor for signs of serotonin toxicity after starting or increasing either drug. Stop both agents and give supportive care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Granisetron?
MediHelp rates the interaction as moderate. Desvenlafaxine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin syndrome has been reported when 5-HT3 antagonists are given with serotonergic antidepressants. The absolute risk is low, but the reaction can be severe. Features include agitation, tremor, hyperreflexia, sweating and fever.
How serious is the interaction between Desvenlafaxine and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient and monitor for signs of serotonin toxicity after starting or increasing either drug. Stop both agents and give supportive care if symptoms appear.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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