Drug interactions
Desvenlafaxine + Haloperidol
Severity: Moderate
Desvenlafaxine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine may raise haloperidol concentrations through weak CYP2D6 inhibition, increasing the risk of extrapyramidal effects and QT prolongation. Both drugs can also affect QT interval on their own.
What this interaction means in plain words
Desvenlafaxine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition reduces haloperidol metabolism, with possible additive QT effects.
What to do
Monitor for extrapyramidal symptoms and check an ECG if QT risk factors are present. Reduce the haloperidol dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Haloperidol?
MediHelp rates the interaction as moderate. Desvenlafaxine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desvenlafaxine may raise haloperidol concentrations through weak CYP2D6 inhibition, increasing the risk of extrapyramidal effects and QT prolongation. Both drugs can also affect QT interval on their own.
How serious is the interaction between Desvenlafaxine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and check an ECG if QT risk factors are present. Reduce the haloperidol dose if adverse effects emerge.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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