Drug interactions
Desvenlafaxine + Lasmiditan
Severity: Moderate
Desvenlafaxine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan causes sedation and other CNS effects, and desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor. Combining them may produce additive drowsiness and dizziness. A theoretical risk of serotonin toxicity also exists, although lasmiditan is a 5-HT1F agonist without vasoconstrictive or clear 5-HT1B/1D activity.
What this interaction means in plain words
Desvenlafaxine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, plus a theoretical additive serotonergic effect.
What to do
Counsel patients to avoid driving or operating machinery for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and for signs of serotonin syndrome such as agitation, tremor, hyperreflexia and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Desvenlafaxine with Lasmiditan?
MediHelp rates the interaction as moderate. Desvenlafaxine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan causes sedation and other CNS effects, and desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor. Combining them may produce additive drowsiness and dizziness. A theoretical risk of serotonin toxicity also exists, although lasmiditan is a 5-HT1F agonist without vasoconstrictive or clear 5-HT1B/1D activity.
How serious is the interaction between Desvenlafaxine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or operating machinery for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and for signs of serotonin syndrome such as agitation, tremor, hyperreflexia and hyperthermia.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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