Drug interactions
Desvenlafaxine + Liposomal doxorubicin
Severity: Minor
Desvenlafaxine and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, and doxorubicin is only a minor CYP2D6 substrate, since its clearance is mainly through aldo-keto reductases and biliary excretion. A clinically meaningful change in doxorubicin exposure is unlikely.
What this interaction means in plain words
Desvenlafaxine and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Liposomal doxorubicin belongs to Oncology.
Why it happens
Weak CYP2D6 inhibition by desvenlafaxine, which has a minor role in doxorubicin metabolism.
What to do
No dose change is needed. Monitor routinely for doxorubicin toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Desvenlafaxine and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak CYP2D6 inhibitor, and doxorubicin is only a minor CYP2D6 substrate, since its clearance is mainly through aldo-keto reductases and biliary excretion. A clinically meaningful change in doxorubicin exposure is unlikely.
How serious is the interaction between Desvenlafaxine and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor routinely for doxorubicin toxicity.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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